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Am J Psychiatry 1990; 147:734-739
Copyright © 1990 by American Psychiatric Association
Magnetic resonance imaging evidence for a defect of cerebral cortical development in autism
J Piven, ML Berthier, SE Starkstein, E Nehme, G Pearlson and S Folstein
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Magnetic resonance imaging (MRI) scans were performed on 13 high-
functioning male autistic subjects and 13 male nonautistic control subjects
comparable in age and nonverbal IQ. Scans were rated for the presence of
cerebral cortical malformations. Five autistic subjects had polymicrogyria,
one had schizencephaly and macrogyria, and one had macrogyria. None of the
control subjects had abnormalities of this type. These abnormalities result
from a defect in the migration of neurons to the cerebral cortex during the
first 6 months of gestation. The detection of these malformations by MRI,
their pathogenesis, and the implications regarding the pathogenesis of
autism are discussed.
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