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Am J Psychiatry 1990; 147:719-724
Copyright © 1990 by American Psychiatric Association
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
ND Volkow, JS Fowler, AP Wolf, D Schlyer, CY Shiue, R Alpert, SL Dewey, J Logan, B Bendriem and D Christman
Medical Department, Brookhaven National Laboratory, Upton, NY 11973- 5000.
To assess the effects of chronic cocaine intoxication on dopamine receptors
in human subjects, the authors evaluated [18F]N- methylspiroperidol binding
using positron emission tomography in 10 cocaine abusers and 10 normal
control subjects. Cocaine abusers who had been detoxified for 1 week or
less showed significantly lower values for uptake of
[18F]N-methylspiroperidol in striatum than the normal subjects, whereas the
cocaine abusers who had been detoxified for 1 month showed values
comparable to those obtained from normal subjects. The authors conclude
that postsynaptic dopamine receptor availability decreases with chronic
cocaine abuse but may recover after a drug-free interval.
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