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Am J Psychiatry 1990; 147:719-724
Copyright © 1990 by American Psychiatric Association
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
ND Volkow, JS Fowler, AP Wolf, D Schlyer, CY Shiue, R Alpert, SL Dewey, J Logan, B Bendriem and D Christman
Medical Department, Brookhaven National Laboratory, Upton, NY 11973- 5000.
To assess the effects of chronic cocaine intoxication on dopamine receptors
in human subjects, the authors evaluated [18F]N- methylspiroperidol binding
using positron emission tomography in 10 cocaine abusers and 10 normal
control subjects. Cocaine abusers who had been detoxified for 1 week or
less showed significantly lower values for uptake of
[18F]N-methylspiroperidol in striatum than the normal subjects, whereas the
cocaine abusers who had been detoxified for 1 month showed values
comparable to those obtained from normal subjects. The authors conclude
that postsynaptic dopamine receptor availability decreases with chronic
cocaine abuse but may recover after a drug-free interval.
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|
|
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|
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|
|
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159(6):
1053 - 1055.
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[PDF]
|
|
|
|
|
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|
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301(3):
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|
|
|
|
|
|
|
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May 1, 2002;
16(3):
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[PDF]
|
|
|
|
|
|
|
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April 1, 2002;
22(7):
2977 - 2988.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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158(8):
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|
|
|
|
|
|
|
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14(4):
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[Abstract]
[PDF]
|
|
|
|
|
|
|
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[Full Text]
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|
|
|
|
|
|
|
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13(4):
337 - 345.
[Abstract]
[PDF]
|
|
|
|
|
|
|
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156(5):
716 - 722.
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[Full Text]
|
|
|
|
|
|
|
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155(6):
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[Full Text]
|
|
|
|
|
|
|
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Am J Psychiatry,
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155(2):
200 - 206.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. I. Leshner
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Science,
October 3, 1997;
278(5335):
45 - 47.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Desai, M. Roy, A. Roy, S. Brown, and D. Smelson
Impaired Color Vision in Cocaine-Withdrawn Patients
Arch Gen Psychiatry,
August 1, 1997;
54(8):
696 - 699.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Roy, A. Roy, J. Williams, L. Weinberger, and D. Smelson
Reduced Blue Cone Electroretinogram in Cocaine-Withdrawn Patients
Arch Gen Psychiatry,
February 1, 1997;
54(2):
153 - 156.
[Abstract]
[PDF]
|
|
|
|
|
|
|
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July 1, 1994;
9(3):
278 - 283.
[Abstract]
[PDF]
|
|
|
|
|
|
|
F. Gawin
Cocaine addiction: psychology and neurophysiology
Science,
March 29, 1991;
251(5001):
1580 - 1586.
[Abstract]
[PDF]
|
|
|
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