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Am J Psychiatry 1990; 147:711-718
Copyright © 1990 by American Psychiatric Association
Personality disorders and treatment outcome in the NIMH Treatment of Depression Collaborative Research Program
MT Shea, PA Pilkonis, E Beckham, JF Collins, I Elkin, SM Sotsky and JP Docherty
Mood, Anxiety, and Personality Disorders Research Branch, NIMH, Rockville, MD 20857.
The authors investigated the relationship between personality disorders and
treatment outcome in the National Institute of Mental Health Treatment of
Depression Collaborative Research Program, which involved 239 outpatients
with major depressive disorder randomly assigned to one of four 16-week
treatment conditions. Patients with personality disorders (74% of the
sample) had a significantly worse outcome in social functioning than
patients without personality disorders and were significantly more likely
to have residual symptoms of depression. There were no significant
differences in work functioning or in mean depression scores at treatment
termination. Outcome was similar for patients in the different clusters of
personality disorders.
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