Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder



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	Articles by Heninger, G. R.

Am J Psychiatry 1990; 147:652-654
Copyright © 1990 by American Psychiatric Association

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Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder

CJ McDougle, WK Goodman, LH Price, PL Delgado, JH Krystal, DS Charney and GR Heninger
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519.

Nine of 17 patients with obsessive-compulsive disorder responded when neuroleptic was added to fluvoxamine with or without lithium. Comorbid occurrence of tic spectrum disorders or of schizotypal personality disorder was associated with response. Abnormalities in brain dopamine and serotonin may be implicated in such patients.

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