Surreptitious drug use by patients in a panic disorder study



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Am J Psychiatry 1990; 147:507-509
Copyright © 1990 by American Psychiatric Association

REGULAR ARTICLES

Surreptitious drug use by patients in a panic disorder study

DB Clark, CB Taylor, WT Roth, C Hayward, A Ehlers, J Margraf and WS Agras
Department of Psychiatry, Stanford University Medical Center, Calif.

In a double-blind, placebo-controlled trial comparing alprazolam and imipramine for panic disorder, serum analysis revealed that a substantial proportion of the patients took explicitly prohibited anxiolytic medication. Excluding these patients changed the results.

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