Am J Psychiatry 1990; 147:457-461
Copyright © 1990 by American Psychiatric Association
Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar I illness: a naturalistic study
M Strober, W Morrell, C Lampert and J Burroughs
Child and Adolescent Mood Disorders Program, University of California School of Medicine, Los Angeles.
The authors conducted an 18-month naturalistic prospective follow-up study
of 37 adolescents whose bipolar I illness had been stabilized with lithium
carbonate during inpatient hospitalization. Thirteen of the patients
discontinued prophylactic lithium therapy shortly after discharge. The
relapse rate of bipolar illness in these 13 patients was nearly three times
higher than the rate in patients who continued lithium prophylaxis without
interruption. Early relapse among lithium- treated patients was associated
with a greater risk of relapsing again. The authors discuss the theoretical
and clinical implications of these findings.
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