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Emergence of intense suicidal preoccupation during fluoxetine treatment

Published Online:https://doi.org/10.1176/ajp.147.2.207

Six depressed patients free of recent serious suicidal ideation developed intense, violent suicidal preoccupation after 2-7 weeks of fluoxetine treatment. This state persisted for as little as 3 days to as long as 3 months after discontinuation of fluoxetine. None of these patients had ever experienced a similar state during treatment with any other psychotropic drug.

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