Am J Psychiatry 1990; 147:1297-1303
Copyright © 1990 by American Psychiatric Association
Cognitive effects of corticosteroids
OM Wolkowitz, VI Reus, H Weingartner, K Thompson, A Breier, A Doran, D Rubinow and D Pickar
Department of Psychiatry, University of California, San Francisco.
In three independent studies with different designs and groups of subjects,
the authors found that 1) depressed patients who did not suppress cortisol
when given dexamethasone (compared to suppressors and normal control
subjects), 2) healthy volunteers given a single 1-mg dose of dexamethasone
(compared to those given placebo), and 3) healthy volunteers given 80
mg/day of prednisone for 5 days (compared to those given placebo) all made
significantly more errors of commission in verbal memory tasks, with no
significant change in their rates of errors of omission. These findings
raise the possibility of specific corticosteroid-related cognitive
impairments.
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