Am J Psychiatry 1990; 147:94-99
Copyright © 1990 by American Psychiatric Association
Neuropsychiatric manifestations of altered thyroid state
KD Denicoff, RT Joffe, MC Lakshmanan, J Robbins and DR Rubinow
Biological Psychiatry Branch, NIMH, Bethesda, MD 20892.
The authors assessed the mood and cognitive effects of sequential T4, T3,
and withdrawal of thyroid hormone replacement on 25 patients who had had
thyroidectomies for thyroid cancer. The patients experienced increased
sadness and anxiety when they were without medication, but not significant
difference in mood was noted between T4 and T3. The patients who
experienced increased affective symptoms when not taking medication were
more likely to have histories of affective illness or mood lability.
