Am J Psychiatry 1989; 146:909-911
Copyright © 1989 by American Psychiatric Association
Open trial of fluoxetine in obsessive-compulsive disorder
MA Jenike, L Buttolph, L Baer, J Ricciardi and A Holland
Harvard Medical School, OCD Clinic and Research Unit, Massachusetts General Hospital, Boston 02114.
A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder
patients significantly improved depressive and obsessive-compulsive
symptoms. Baseline depression scores were not related to improvement on two
obsessive-compulsive scales. The results reinforce the hypothesis of
serotonergic abnormalities in obsessive-compulsive disorder.
