Am J Psychiatry 1989; 146:652-655
Copyright © 1989 by American Psychiatric Association
Growth rate in adolescents with obsessive-compulsive disorder
SD Hamburger, S Swedo, A Whitaker, M Davies and JL Rapoport
Child Psychiatry Branch, NIMH, Bethesda, MD 20892.
In an epidemiological study of 5,596 high school students, the authors
identified 20 adolescents with obsessive-compulsive disorder and compared
their physical size to that of adolescents of the same sex with no
obsessive-compulsive symptoms. The obsessive-compulsive boys (N = 11) were
shorter and weighed less than the other boys (N = 2,479) and were shorter
than a subsample of normal boys (N = 33) and boys with other psychiatric
diagnoses (N = 16). Regression analysis showed a flatter growth pattern
through adolescence for the obsessive-compulsive boys (although within the
95% confidence limits for the other boys), suggesting a subtle
neuroendocrine dysfunction in obsessive-compulsive disorder.