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Am J Psychiatry 1989; 146:652-655
Copyright © 1989 by American Psychiatric Association


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Growth rate in adolescents with obsessive-compulsive disorder

SD Hamburger, S Swedo, A Whitaker, M Davies and JL Rapoport
Child Psychiatry Branch, NIMH, Bethesda, MD 20892.

In an epidemiological study of 5,596 high school students, the authors identified 20 adolescents with obsessive-compulsive disorder and compared their physical size to that of adolescents of the same sex with no obsessive-compulsive symptoms. The obsessive-compulsive boys (N = 11) were shorter and weighed less than the other boys (N = 2,479) and were shorter than a subsample of normal boys (N = 33) and boys with other psychiatric diagnoses (N = 16). Regression analysis showed a flatter growth pattern through adolescence for the obsessive-compulsive boys (although within the 95% confidence limits for the other boys), suggesting a subtle neuroendocrine dysfunction in obsessive-compulsive disorder.


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J.V. Lucey
BAP/SKB Young Psychopharmacologist Award Towards a neuroendocrinology of obsessive-compulsive disorder
J Psychopharmacol, January 1, 1994; 8(4): 250 - 257.
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