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Am J Psychiatry 1989; 146:627-634
Copyright © 1989 by American Psychiatric Association


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Lateralization of dementia of depression in stroke patients

K Bolla-Wilson, RG Robinson, SE Starkstein, J Boston and TR Price
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21224.

In a group of stroke patients with left-hemisphere lesions, those with major depression performed significantly below nondepressed patients on four of nine cognitive domains examined with a neuropsychological test battery. Among patients with right-hemisphere stroke, those with major depression did not perform below nondepressed patients on any of the nine cognitive domains. The differential effect of depression on cognitive performance between left- and right-hemisphere lesion groups could not be accounted for by demographic variables, neurological symptoms, lesion location, or lesion size. Poststroke major depression appeared to produce a decline in cognitive performance or dementia of depression that depended on the laterality of the lesion.


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