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Am J Psychiatry 1989; 146:627-634
Copyright © 1989 by American Psychiatric Association
Lateralization of dementia of depression in stroke patients
K Bolla-Wilson, RG Robinson, SE Starkstein, J Boston and TR Price
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21224.
In a group of stroke patients with left-hemisphere lesions, those with
major depression performed significantly below nondepressed patients on
four of nine cognitive domains examined with a neuropsychological test
battery. Among patients with right-hemisphere stroke, those with major
depression did not perform below nondepressed patients on any of the nine
cognitive domains. The differential effect of depression on cognitive
performance between left- and right-hemisphere lesion groups could not be
accounted for by demographic variables, neurological symptoms, lesion
location, or lesion size. Poststroke major depression appeared to produce a
decline in cognitive performance or dementia of depression that depended on
the laterality of the lesion.
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