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Am J Psychiatry 1989; 146:538-539
Copyright © 1989 by American Psychiatric Association

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Behavioral hyporeactivity to physostigmine in detoxified primary alcoholics

DS Janowsky, SC Risch, M Irwin and MA Schuckit
Psychiatry Service, San Diego, VA Medical Center.

Changes in anergia/inhibition, mood, and pulse rate induced by intravenous physostigmine were significantly less pronounced in 26 patients with primary alcoholism than in 36 normal control subjects. These results suggest possible abnormalities in central cholinergic functioning in primary alcoholics.




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