A controlled trial of desipramine in 18 men with posttraumatic stress disorder



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Am J Psychiatry 1989; 146:513-516
Copyright © 1989 by American Psychiatric Association

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A controlled trial of desipramine in 18 men with posttraumatic stress disorder

C Reist, CD Kauffmann, RJ Haier, C Sangdahl, EM DeMet, A Chicz-DeMet and JN Nelson
Department of Psychiatry, VA Medical Center, Long Beach, CA 90822.

Eighteen male U.S. veterans meeting DSM-III criteria for posttraumatic stress disorder (PTSD) completed a 4-week double-blind, crossover study comparing administration of 200 mg/day of desipramine with placebo. Response was measured by using the Beck Depression Inventory, the Hamilton Rating Scale for Depression, the Hamilton Rating Scale for Anxiety, and the Impact of Event Scale. Overall, the only apparent response to desipramine was in some symptoms of depression; there were no changes in anxiety and other PTSD symptoms.

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