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Am J Psychiatry 1989; 146:464-472
Copyright © 1989 by American Psychiatric Association
Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study
RL Suddath, MF Casanova, TE Goldberg, DG Daniel, JR Kelsoe Jr and DR Weinberger
Clinical Brain Disorders Branch, NIMH Neurosciences Center, Saint Elizabeths Hospital, Washington, DC 20032.
Although numerous studies have confirmed the presence of larger cerebral
ventricles in schizophrenia, the locus of tissue loss remains elusive. By
analyzing magnetic resonance scans with computerized image analysis, the
authors determined gray and white matter volumes in the temporal lobes and
prefrontal regions of 17 patients with schizophrenia and 17 age- and
sex-matched normal subjects. The volume of temporal lobe gray matter was
20% smaller in the patients than in the control subjects. The lateral
ventricular volume was 67% larger in the patients and, when normalized for
brain size, correlated inversely with the volume of temporal lobe gray
matter.
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