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Am J Psychiatry 1989; 146:373-376
Copyright © 1989 by American Psychiatric Association
Doxepin as an adjunct to smoking cessation: a double-blind pilot study
NB Edwards, JK Murphy, AD Downs, BJ Ackerman and TL Rosenthal
Department of Psychiatry, University of Tennessee College of Medicine, Memphis 38105.
In a double-blind study, 19 adults received bedtime doses of either 150 mg
of doxepin hydrochloride (N = 9) or placebo (N = 10). After 3 weeks the
subjects were instructed to stop smoking and continue taking medication for
4 additional weeks. Cessation was reported by all nine doxepin subjects 1
week after cessation and by seven doxepin subjects 9 weeks after cessation.
One placebo subject reported cessation. Cotinine assays generally confirmed
cessation but were subject to interpretation. Doxepin assays suggested that
the precessation level was associated with cessation. Further studies with
larger samples and extended follow-up are needed to determine the
reliability of these results.
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