Am J Psychiatry 1988; 145:1110-1114
Copyright © 1988 by American Psychiatric Association
S-adenosylmethionine treatment of depression: a controlled clinical trial
KM Bell, L Plon, WE Bunney Jr and SG Potkin
University of California, Irvine Medical Center, Orange 92668.
The antidepressant properties of S-adenosylmethionine, an endogenous methyl
donor, were studied in inpatients who met the DSM-III criteria for major
depression. Nine patients given intravenous S- adenosylmethionine and nine
given low oral doses of imipramine were compared in a double-blind design
for 14 days. The S-adenosylmethionine produced superior results by the end
of the first week of treatment. By the end of the second week, 66% of the
S-adenosylmethionine patients had a clinically significant improvement in
depressive symptoms, compared to 22% of the imipramine patients. Side
effects appeared to be fewer with S-adenosylmethionine than with imipramine
during the last 5 days of the study.
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