Anterior pituitary, adrenal, and gonadal hormones during cocaine withdrawal



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Am J Psychiatry 1988; 145:1094-1098
Copyright © 1988 by American Psychiatric Association

REGULAR ARTICLES

Anterior pituitary, adrenal, and gonadal hormones during cocaine withdrawal

JH Mendelson, SK Teoh, U Lange, NK Mello, R Weiss, A Skupny and J Ellingboe
Alcohol and Drug Abuse Research Center, Harvard Medical School/McLean Hospital, Belmont, MA 02178.

Plasma luteinizing hormone (LH), prolactin, testosterone, and cortisol levels were determined in 16 patients after hospital admission for cocaine abuse, during the course of 4 weeks of hospitalization, and before discharge. Hyperprolactinemia was found at admission (mean +/- SD, 27.5 +/- 10.2 ng/ml) and persisted until discharge (mean +/- SD, 28.7 +/- 10.8 ng/ml). Plasma LH, testosterone, and cortisol levels were within normal limits. These findings suggest that persistent elevation of plasma prolactin levels after cocaine withdrawal may reflect a chronic cocaine-induced derangement in neural dopaminergic regulatory systems.

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