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Am J Psychiatry 1988; 145:748-750
Copyright © 1988 by American Psychiatric Association

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A carbamazepine trial in chronic, treatment-refractory schizophrenia

J Sramek, J Herrera, J Costa, C Heh, T Tran-Johnson and G Simpson
Clinical Research Unit, Metropolitan State Hospital, Norwalk, CA 90650.

Carbamazepine was given to 12 chronic, treatment-refractory schizophrenic patients for 5 weeks. No overall change was found, but four patients significantly improved while eight worsened. Given the paucity of successful treatments for refractory schizophrenia, further study of carbamazepine appears warranted.




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