Prolactin response to tryptophan during mianserin treatment



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	Articles by Cowen, P. J.

Am J Psychiatry 1988; 145:740-741
Copyright © 1988 by American Psychiatric Association

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Prolactin response to tryptophan during mianserin treatment

PJ Cowen
Department of Psychiatry, Oxford University, United Kingdom.

Unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5- hydroxytryptamine (5-HT) precursor tryptophan in nine patients with major depression. Antidepressant drugs apparently produce dissimilar effects on this aspect of brain 5-HT function in depressed patients.

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