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Am J Psychiatry 1988; 145:281-285
Copyright © 1988 by American Psychiatric Association
Toward rational pharmacotherapy for posttraumatic stress disorder: an interim report
MJ Friedman
Psychiatry Service, VA Hospital, White River Junction, VT.
There is growing evidence that medication can alleviate symptoms associated
with posttraumatic stress disorder (PTSD). Recent research also suggests
that PTSD has a unique biological profile consisting of alterations in
sympathetic arousal, the neuroendocrine system, and the sleep/dream cycle.
This profile distinguishes PTSD from both major depression and panic
disorder. Medication appears to alleviate PTSD symptoms associated with
sympathetic hyperarousal and intrusive recollections of the trauma but
seems ineffective against avoidant symptoms. Pharmacotherapy alone is
rarely sufficient to provide complete remission of PTSD. Symptom relief
provided by medication facilitates the patient's participation in
individual, behavioral, or group psychotherapy.
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