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Am J Psychiatry 1988; 145:179-184
Copyright © 1988 by American Psychiatric Association
Rapid cycling affective disorder: contributing factors and treatment responses in 51 patients
TA Wehr, DA Sack, NE Rosenthal and RW Cowdry
Clinical Psychobiology Branch, NIMH, Bethesda, MD 20892.
For 51 patients with rapid cycling affective disorder, clinical and family
history data indicated that the illness was phenotypically and genetically
related to more typical forms of affective disorder, was characterized by a
bipolar course (100%), and was more common in women (92%). Manic-depressive
cycles were separate from menstrual cycles. At the time of onset of rapid
cycling, 73% of the patients were taking antidepressant drugs; the
continuation of rapid cycling was associated with antidepressant drug
therapy in 51% of the patients. Although most patients had been referred to
a research ward because they were considered to be refractory to treatment,
37% attained essentially complete remissions, usually during treatment with
lithium and/or monoamine oxidase inhibitors.
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