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Am J Psychiatry 1988; 145:154-163
Copyright © 1988 by American Psychiatric Association
Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect
RC Shelton, CN Karson, AR Doran, D Pickar, LB Bigelow and DR Weinberger
Clinical Brain Disorders Branch, NIMH, Washington, D.C.
To replicate earlier findings of central and cortical cerebral structural
abnormalities and to further examine specific prefrontal cortical
irregularities in schizophrenia, the authors examined computerized
tomographic (CT) scans of 71 patients with chronic schizophrenia and 30
normal volunteer control subjects for ventricle- brain ratio (VBR), third
ventricle width, and prominence of cortical markings in a generalized
(parieto-occipital) distribution compared with the prefrontal area.
Patients showed significantly larger VBRs and third ventricle widths than
control subjects. Patients also showed significantly greater prefrontal
markings in terms of both the number of individuals affected and the degree
of difference. The relative differences on measures of VBR and prefrontal
atrophy did not appear gender related, but the difference in third
ventricle width between schizophrenic and control women was greater than
that between schizophrenic and control men.
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