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Am J Psychiatry 1988; 145:1560-1563
Copyright © 1988 by American Psychiatric Association

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Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder

LR Baxter Jr, JM Schwartz, JC Mazziotta, ME Phelps, JJ Pahl, BH Guze and L Fairbanks
Department of Radiological Sciences, University of California, Los Angeles.

The authors compared 10 nondepressed patients with obsessive-compulsive disorder with 10 normal control subjects of the same sex and similar age for cerebral glucose metabolic rates obtained using positron emission tomography. Obsessive-compulsive patients showed significantly elevated metabolic rates in the whole cerebral hemispheres, heads of the caudate nuclei, orbital gyri, and the orbital gyri relative to the ipsilateral hemisphere (the orbital-hemisphere ratio). These results are similar to those the authors reported previously for another group of obsessive-compulsive patients and normal control subjects.


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