Am J Psychiatry 1988; 145:1560-1563
Copyright © 1988 by American Psychiatric Association
Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder
LR Baxter Jr, JM Schwartz, JC Mazziotta, ME Phelps, JJ Pahl, BH Guze and L Fairbanks
Department of Radiological Sciences, University of California, Los Angeles.
The authors compared 10 nondepressed patients with obsessive-compulsive
disorder with 10 normal control subjects of the same sex and similar age
for cerebral glucose metabolic rates obtained using positron emission
tomography. Obsessive-compulsive patients showed significantly elevated
metabolic rates in the whole cerebral hemispheres, heads of the caudate
nuclei, orbital gyri, and the orbital gyri relative to the ipsilateral
hemisphere (the orbital-hemisphere ratio). These results are similar to
those the authors reported previously for another group of
obsessive-compulsive patients and normal control subjects.
This article has been cited by other articles:
|
|
|
|
 
B. J. Harrison, C. Soriano-Mas, J. Pujol, H. Ortiz, M. Lopez-Sola, R. Hernandez-Ribas, J. Deus, P. Alonso, M. Yucel, C. Pantelis, et al.
Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
November 1, 2009;
66(11):
1189 - 1200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Agarwal, D. Biswas, and R. Sadhu
Treatment for Late-Onset Obsessive-Compulsive Disorder with Parkinsonism
J Neuropsychiatry Clin Neurosci,
August 1, 2008;
20(3):
331 - 336.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. B. McCracken and A. A. Grace
High-Frequency Deep Brain Stimulation of the Nucleus Accumbens Region Suppresses Neuronal Activity and Selectively Modulates Afferent Drive in Rat Orbitofrontal Cortex In Vivo
J. Neurosci.,
November 14, 2007;
27(46):
12601 - 12610.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Remijnse, M. M. A. Nielen, A. J. L. M. van Balkom, D. C. Cath, P. van Oppen, H. B. M. Uylings, and D. J. Veltman
Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder.
Arch Gen Psychiatry,
November 1, 2006;
63(11):
1225 - 1236.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Van Laere, B. Nuttin, L. Gabriels, P. Dupont, S. Rasmussen, B. D. Greenberg, and P. Cosyns
Metabolic Imaging of Anterior Capsular Stimulation in Refractory Obsessive-Compulsive Disorder: A Key Role for the Subgenual Anterior Cingulate and Ventral Striatum
J. Nucl. Med.,
May 1, 2006;
47(5):
740 - 747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Saxena, A. L. Brody, K. M. Maidment, E. C. Smith, N. Zohrabi, E. Katz, S. K. Baker, and L. R. Baxter Jr.
Cerebral Glucose Metabolism in Obsessive-Compulsive Hoarding
Am J Psychiatry,
June 1, 2004;
161(6):
1038 - 1048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Mataix-Cols, S. Wooderson, N. Lawrence, M. J. Brammer, A. Speckens, and M. L. Phillips
Distinct Neural Correlates of Washing, Checking, and Hoarding Symptom Dimensions in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
June 1, 2004;
61(6):
564 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J S Kwon, Y-W Shin, C-W Kim, Y I Kim, T Youn, M H Han, K-H Chang, and J-J Kim
Similarity and disparity of obsessive-compulsive disorder and schizophrenia in MR volumetric abnormalities of the hippocampus-amygdala complex
J. Neurol. Neurosurg. Psychiatry,
July 1, 2003;
74(7):
962 - 964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Y. Hardan, M. Kilpatrick, M. S. Keshavan, and N. J. Minshew
Motor Performance and Anatomic Magnetic Resonance Imaging (MRI) of the Basal Ganglia in Autism
J Child Neurol,
May 1, 2003;
18(5):
317 - 324.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B. J. Casey, K. M. Thomas, M. C. Davidson, K. Kunz, and P. L. Franzen
Dissociating Striatal and Hippocampal Function Developmentally with a Stimulus-Response Compatibility Task
J. Neurosci.,
October 1, 2002;
22(19):
8647 - 8652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Saxena, A. L. Brody, M. L. Ho, S. Alborzian, K. M. Maidment, N. Zohrabi, M. K. Ho, S.-C. Huang, H.-M. Wu, and L. R. Baxter Jr
Differential Cerebral Metabolic Changes With Paroxetine Treatment of Obsessive-Compulsive Disorder vs Major Depression
Arch Gen Psychiatry,
March 1, 2002;
59(3):
250 - 261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-J. KIM, M. C. LEE, J. KIM, I. Y. KIM, S. I. KIM, M. HEE HAN, K.-H. CHANG, and J. S. KWON
Grey matter abnormalities in obsessive--compulsive disorder: Statistical parametric mapping of segmented magnetic resonance images
The British Journal of Psychiatry,
October 1, 2001;
179(4):
330 - 334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Laven and E. M. Bednarczyk
CNS Assessment Using Functional Neuro-PET Imaging
Journal of Pharmacy Practice,
August 1, 2001;
14(4):
308 - 331.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. L. Grimes, L. B. McCullough, M. E. Kunik, V. Molinari, and R. H. Workman Jr.
Informed Consent and Neuroanatomic Correlates of Intentionality and Voluntariness Among Psychiatric Patients
Psychiatr Serv,
December 1, 2000;
51(12):
1561 - 1567.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Szeszko, D. Robinson, J. Ma. J. Alvir, R. M. Bilder, T. Lencz, M. Ashtari, H. Wu, and B. Bogerts
Orbital Frontal and Amygdala Volume Reductions in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
October 1, 1999;
56(10):
913 - 919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Purcell, P. Maruff, M. Kyrios, and C. Pantelis
Neuropsychological Deficits in Obsessive-compulsive Disorder: A Comparison With Unipolar Depression, Panic Disorder, and Normal Controls
Arch Gen Psychiatry,
May 1, 1998;
55(5):
415 - 423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. S. Peterson, P. Skudlarski, A. W. Anderson, H. Zhang, J. C. Gatenby, C. M. Lacadie, J. F. Leckman, and J. C. Gore
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Arch Gen Psychiatry,
April 1, 1998;
55(4):
326 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Glod and D. Cawley
The Neurobiology of Obsessive-Compulsive Disorder
Journal of the American Psychiatric Nurses Association,
August 1, 1997;
3(4):
120 - 122.
[PDF]
|
|
|
|
|
|
|
A. L. Malizia
The frontal lobes and neurosurgery for psychiatric disorders
J Psychopharmacol,
January 1, 1997;
11(2):
179 - 187.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. H. Aylward, G. J. Harris, R. Hoehn-Saric, P. E. Barta, S. R. Machlin, and G. D. Pearlson
Normal Caudate Nucleus in Obsessive-compulsive Disorder Assessed by Quantitative Neuroimaging
Arch Gen Psychiatry,
July 1, 1996;
53(7):
577 - 584.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H. C. Breiter, S. L. Rauch, K. K. Kwong, J. R. Baker, R. M. Weisskoff, D. N. Kennedy, A. D. Kendrick, T. L. Davis, A. Jiang, M. S. Cohen, et al.
Functional Magnetic Resonance Imaging of Symptom Provocation in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
July 1, 1996;
53(7):
595 - 606.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Robinson, H. Wu, R. A. Munne, M. Ashtari, J. Ma. J. Alvir, G. Lerner, A. Koreen, K. Cole, and B. Bogerts
Reduced Caudate Nucleus Volume in Obsessive-compulsive Disorder
Arch Gen Psychiatry,
May 1, 1995;
52(5):
393 - 398.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. K. Afifi
Topical Review: Basal Ganglia: Functional Anatomy and Physiology. Part 2
J Child Neurol,
October 1, 1994;
9(4):
352 - 361.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J.V. Lucey
BAP/SKB Young Psychopharmacologist Award Towards a neuroendocrinology of obsessive-compulsive disorder
J Psychopharmacol,
January 1, 1994;
8(4):
250 - 257.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. L. Rauch, M. A. Jenike, N. M. Alpert, L. Baer, H. C. R. Breiter, C. R. Savage, and A. J. Fischman
Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15--Labeled Carbon Dioxide and Positron Emission Tomography
Arch Gen Psychiatry,
January 1, 1994;
51(1):
62 - 70.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. J. Harris, G. D. Pearlson, and R. Hoehn-Saric
Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder
Arch Gen Psychiatry,
June 1, 1993;
50(6):
498 - 499.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. R. Baxter Jr, J. M. Schwartz, K. S. Bergman, M. P. Szuba, B. H. Guze, J. C. Mazziotta, A. Alazraki, C. E. Selin, H.-K. Ferng, P. Munford, et al.
Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder
Arch Gen Psychiatry,
September 1, 1992;
49(9):
681 - 689.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. E. Swedo, P. Pietrini, H. L. Leonard, M. B. Schapiro, D. C. Rettew, E. L. Goldberger, S. I. Rapoport, J. L. Rapoport, and C. L. Grady
Cerebral Glucose Metabolism in Childhood-Onset Obsessive-Compulsive Disorder: Revisualization During Pharmacotherapy
Arch Gen Psychiatry,
September 1, 1992;
49(9):
690 - 694.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. T. Rubin, J. Villanueva-Meyer, J. Ananth, P. G. Trajmar, and I. Mena
Regional Xenon 133 Cerebral Blood Flow and Cerebral Technetium 99m HMPAO Uptake in Unmedicated Patients With Obsessive-Compulsive Disorder and Matched Normal Control Subjects: Determination by High-Resolution Single-Photon Emission Computed Tomography
Arch Gen Psychiatry,
September 1, 1992;
49(9):
695 - 702.
[Abstract]
[PDF]
|
|
|
|
|
|
|
T. R. Insel
Toward a Neuroanatomy of Obsessive-Compulsive Disorder
Arch Gen Psychiatry,
September 1, 1992;
49(9):
739 - 744.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. X. Freedman and S. M. Stahl
Psychiatry
JAMA,
July 15, 1992;
268(3):
403 - 405.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Altemus, T. Pigott, K. T. Kalogeras, M. Demitrack, B. Dubbert, D. L. Murphy, and P. W. Gold
Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder
Arch Gen Psychiatry,
January 1, 1992;
49(1):
9 - 20.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Benkelfat, T. E. Nordahl, W. E. Semple, A. C. King, D. L. Murphy, and R. M. Cohen
Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder: Patients Treated With Clomipramine
Arch Gen Psychiatry,
September 1, 1990;
47(9):
840 - 848.
[Abstract]
[PDF]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1988
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
