Possible synergism between fluoxetine and lithium in refractory depression



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	Articles by Pope, H. G., Jr
	Articles by Nixon, R. A.

Am J Psychiatry 1988; 145:1292-1294
Copyright © 1988 by American Psychiatric Association

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Possible synergism between fluoxetine and lithium in refractory depression

HG Pope Jr, SL McElroy and RA Nixon
Epidemiology Laboratory, McLean Hospital, Belmont, MA 02178.

Five depressed patients who had shown no improvement with trials of antidepressants from several chemical families, including fluoxetine, responded when lithium was given in conjunction with fluoxetine. Lithium augmentation of fluoxetine may represent a useful strategy in refractory depression.

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