An open trial of buspirone in obsessive-compulsive disorder



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Am J Psychiatry 1988; 145:1285-1286
Copyright © 1988 by American Psychiatric Association

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An open trial of buspirone in obsessive-compulsive disorder

MA Jenike and L Baer
Harvard Medical School, Obsessive Compulsive Disorders Clinic and Research Unit, Massachusetts General Hospital, Boston 02114.

Of 14 patients with obsessive-compulsive disorder who entered an 8-week open trial of buspirone, none improved. The ineffectiveness of buspirone may shed light on the serotonergic hypothesis that has been proposed for this disorder.

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