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Am J Psychiatry 1988; 145:11-18
Copyright © 1988 by American Psychiatric Association
Significance and meaning of neurological signs in schizophrenia
DW Heinrichs and RW Buchanan
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228.
The authors review studies of abnormal signs on clinical neurological
examination of schizophrenic patients. In spite of a number of methodologic
limitations, the cumulative evidence strongly argues that there are more
neurological signs in schizophrenic patients than in nonpsychiatric control
subjects. Although less consistent, there is considerable evidence of more
neurological signs in schizophrenic patients than in patients with
affective disorders or with mixed, nonpsychotic disorders. The existing
literature suggests several preliminary hypotheses with respect to
neuroanatomical localization of neurological signs, subtyping of
schizophrenia, and utility of studies of relatives at high risk and family
history studies. Directions for future research in these areas are
described.
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