Am J Psychiatry 1987; 144:1207-1209
Copyright © 1987 by American Psychiatric Association
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication
AJ Giannini, RH Loiselle, LR DiMarzio and MC Giannini
The authors studied 40 white men with acute phencyclidine (PCP)
intoxication. On a random basis, 10 were treated with ascorbic acid, 10
with placebo, 10 with haloperidol, and 10 with a combination of ascorbic
acid and haloperidol. While haloperidol was significantly more effective
than ascorbic acid, the combination was significantly more effective than
either used alone. This combination may have a specific antipsychotic role
in the emergency treatment of PCP psychosis.
