Am J Psychiatry 1987; 144:1123-1134
Copyright © 1987 by American Psychiatric Association
Alterations in immunocompetence during stress, bereavement, and depression: focus on neuroendocrine regulation
JR Calabrese, MA Kling and PW Gold
There is now clear evidence that stress, bereavement, and depression can
compromise specific components of the immunologic apparatus. The first part
of this paper gives an overview of fundamental immunology and is followed
by a review of the patterns, possible causes, and potential clinical
implications of abnormal immunoregulation. After a discussion of the
immunomodulating properties of glucocorticoids, the authors conclude with
an overview of the many factors that mediate the complex interdependence
between immunologic function, the brain, and neuroendocrine regulation.
