Am J Psychiatry 1987; 144:1080-1082
Copyright © 1987 by American Psychiatric Association
CO2 challenge of patients with panic disorder
MR Fyer, J Uy, J Martinez, R Goetz, DF Klein, A Fyer, MR Liebowitz and J Gorman
In an open trial, five of eight panic disorder patients and none of five
control subjects panicked after inhalation of two breaths of 35% CO2 and
65% O2; none panicked after placebo. Using 35% CO2 to induce panic is safe,
simple, and well tolerated and may provide a valuable laboratory model of
panic.
