Am J Psychiatry 1987; 144:330-333
Copyright © 1987 by American Psychiatric Association
High rate of affective disorders in probands with attention deficit disorder and in their relatives: a controlled family study
J Biederman, K Munir, D Knee, M Armentano, S Autor, C Waternaux and M Tsuang
In a controlled family study of attention deficit disorder, data were
collected on first-degree relatives of 22 children with attention deficit
disorder and 20 normal children. The rate of major affective disorder was
significantly higher in the attention deficit disorder probands (32%) and
their relatives (27%) than in the normal control subjects (0%) and their
relatives (6%). The findings indicate that attention deficit disorder is
associated with higher risk for affective disorder and suggest that
probands who have both disorders may represent a distinct subgroup.
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