Blunted aldosterone and ACTH release after human CRH administration in depressed patients



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Am J Psychiatry 1987; 144:229-231
Copyright © 1987 by American Psychiatric Association

REGULAR ARTICLES

Blunted aldosterone and ACTH release after human CRH administration in depressed patients

F Holsboer, A Gerken, GK Stalla and OA Muller

The authors measured pituitary adrenocortical responses to human corticotropin-releasing hormone (CRH) in 10 patients with a major depressive episode and 10 matched control subjects. Depressed patients had a significantly lower aldosterone and ACTH release, but cortisol and corticosterone responses were not different between groups.

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