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Am J Psychiatry 1986; 143:1170-1171
Copyright © 1986 by American Psychiatric Association

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Exacerbation of schizophrenia associated with amantadine

Z Nestelbaum, SG Siris, A Rifkin, H Klar and GT Reardon

Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication. Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.




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