Am J Psychiatry 1986; 143:1098-1105
Copyright © 1986 by American Psychiatric Association
A DSM-III family study of the nonschizophrenic psychotic disorders
KS Kendler, AM Gruenberg and MT Tsuang
The authors conducted a blind DSM-III family study based on probands
diagnosed from long-term follow-up information as having schizophreniform
disorder, schizoaffective disorder, or psychotic affective illness. The
pattern of psychopathology in relatives of schizophreniform probands
closely resembled that found previously in relatives of schizophrenic
probands. Relatives of schizoaffective probands had an excess risk for
schizophrenia, other psychoses, and bipolar illness. The pattern of illness
found in relatives of the probands meeting Research Diagnostic Criteria for
mainly schizophrenic schizoaffective disorder appeared indistinguishable
from that of relatives of schizophrenic probands. Relatives of probands
with psychotic affective disorder had an excess risk for schizophrenia and
for unipolar and bipolar affective disorder.
