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Am J Psychiatry 1986; 143:912-914
Copyright © 1986 by American Psychiatric Association

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Essential fatty acid supplementation in tardive dyskinesia

A Wolkin, B Jordan, E Peselow, M Rubinstein and J Rotrosen

Preclinical and clinical observations suggest that enhancement of prostaglandin activity inhibits catecholamine release and may have antidyskinetic effects. A double-blind therapeutic trial with prostaglandin precursor essential fatty acids was conducted in 16 patients with tardive dyskinesia. No beneficial effects were seen.




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