Am J Psychiatry 1986; 143:756-759
Copyright © 1986 by American Psychiatric Association
Clinical and biochemical features of depression in Parkinson's disease
R Mayeux, Y Stern, JB Williams, L Cote, A Frantz and I Dyrenfurth
Among 49 consecutive patients with Parkinson's disease, 40% were depressed
according to DSM-III; they had major depression or dysthymic disorder
accompanied by sleep disturbance, fatigue, psychomotor retardation, loss of
self-esteem, and excessive guilt. During a 10-day dopamine-free period,
lumbar puncture was performed to measure the metabolites of dopamine,
serotonin, and norepinephrine. Patients were given an overnight
dexamethasone suppression test, and the effects of thyrotropin-releasing
hormone and L-dopa on plasma growth hormone and prolactin were examined.
Level of CSF 5-hydroxyindoleacetic acid was lowest in parkinsonian patients
with major depression and was related to psychomotor retardation and loss
of self-esteem.
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