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Am J Psychiatry 1986; 143:652-653
Copyright © 1986 by American Psychiatric Association

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Alprazolam-induced manic episode in two patients with panic disorder

JC Pecknold and D Fleury

Two patients treated with alprazolam for panic disorder and agoraphobia developed a manic episode. Two biological markers--shortened REM latency and nonsuppression on the dexamethasone suppression test-- suggested that both patients may have had an underlying affective disorder.




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