Am J Psychiatry 1986; 143:650-651
Copyright © 1986 by American Psychiatric Association
Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?
GW Arana, DC Goff, H Friedman, M Ornsteen, DJ Greenblatt, B Black and RI Shader
Seven psychotic patients' plasma haloperidol levels, determined with
gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment
was instituted. Two patients' levels became undetectable, and their
symptoms worsened. Haloperidol level monitoring may be required for
patients given both haloperidol and carbamazepine.
