Am J Psychiatry 1986; 143:457-462
Copyright © 1986 by American Psychiatric Association
Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: lack of association with affective illness
E Richelson, K Snyder, J Carlson, M Johnson, S Turner, A Lumry, E Boerwinkle and CF Sing
The authors measured the in vitro lithium ion ratio and maximal rate of
sodium-lithium countertransport in erythrocytes of 739 randomly selected
blood donors and 42 manic-depressive patients to determine the frequency
distributions of these two variables in a general population and their
relationship to one another and to affective illness. A large
interindividual variation was found for the ratio and countertransport, and
there was evidence of bimodality in the frequency distributions for these
two traits. There was a moderate negative correlation (r = -.61) between
the ratio and countertransport for 126 individuals. Neither the ratio nor
countertransport was found to be a useful marker for affective illness.
