Depression in women treated for gynecological cancer: clinical and neuroendocrine assessment



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Am J Psychiatry 1986; 143:447-452
Copyright © 1986 by American Psychiatric Association

REGULAR ARTICLES

Depression in women treated for gynecological cancer: clinical and neuroendocrine assessment

DL Evans, CF McCartney, CB Nemeroff, D Raft, D Quade, RN Golden, JJ Haggerty Jr, V Holmes, JS Simon and M Droba

To determine the prevalence of major depression in cancer patients and assess the usefulness of the dexamethasone suppression test (DST) and the thyrotropin-releasing hormone (TRH) stimulation test for diagnosing major depression in these patients, the authors studied 83 women hospitalized for gynecological cancer. Nineteen (23%) had major depression according to DSM-III criteria. The sensitivity and specificity of the DST were 40% and 88%, respectively. No relationship between DST and TRH test results was found. These findings indicate a high prevalence of depression in cancer patients, but further research on these tests in cancer patients is needed; their routine use with cancer patients is premature at this time.

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