Am J Psychiatry 1986; 143:175-180
Copyright © 1986 by American Psychiatric Association
Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression
AS Kling, EJ Metter, WH Riege and DE Kuhl
Using [18F]fluorodeoxyglucose and positron emission tomography (PET), the
authors examined the regional brain glucose metabolism of six patients with
chronic schizophrenia, six patients with chronic depression, and 12 normal
control subjects. Three schizophrenic and four depressive patients had CAT
scans that showed enlarged ventricles (ventricle-brain ratios higher than
9.0) and widened sylvian fissures. The PET scans of the schizophrenic and
depressed patients did not differ significantly from those of the
age-matched controls, and a previously reported metabolic "hypofrontality"
was not confirmed. The patients with enlarged ventricles and widened
sylvian fissures tended to have lower global metabolism.
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