Am J Psychiatry 1986; 143:1608-1609
Copyright © 1986 by American Psychiatric Association
Comparison of clonidine and lithium in the treatment of mania
AJ Giannini, GA Pascarzi, RH Loiselle, WA Price and MC Giannini
The authors compared the antimanic effects of clonidine with lithium
carbonate in a double-blind crossover design with 24 volunteers. Lithium
was observed to be more effective than clonidine. Some patients reported
experiencing hypotension (N=8) and depression (N=7) while taking clonidine.