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Am J Psychiatry 1986; 143:1603-1605
Copyright © 1986 by American Psychiatric Association

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Paradoxical effects of amitriptyline on borderline patients

PH Soloff, A George, RS Nathan, PM Schulz and JM Perel

A paradoxical increase in suicide threats, paranoid ideation, and demanding and assaultive behavior occurred among 15 borderline inpatients receiving amitriptyline in a double-blind study. This pattern differed significantly from that of 14 nonresponding patients receiving placebo.


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[Abstract] [PDF]


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