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Am J Psychiatry 1986; 143:1464-1466
Copyright © 1986 by American Psychiatric Association

REGULAR ARTICLES

Withdrawal syndrome with gradual tapering of alprazolam

TA Mellman and TW Uhde

The clinical and biological correlates of gradual alprazolam withdrawal were investigated in 10 patients in a double-blind, placebo-controlled trial. During gradual alprazolam withdrawal, anxiety and plasma cortisol levels were higher than during a postwithdrawal medication- free period.




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