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Am J Psychiatry 1986; 143:85-87
Copyright © 1986 by American Psychiatric Association


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Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

OM Wolkowitz, D Pickar, AR Doran, A Breier, J Tarell and SM Paul

Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction or discontinuation of alprazolam.





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