Am J Psychiatry 1986; 143:24-28
Copyright © 1986 by American Psychiatric Association
The persistent risk of chronicity in recurrent episodes of nonbipolar major depressive disorder: a prospective follow-up
MB Keller, PW Lavori, J Rice, W Coryell and RM Hirschfeld
The authors report on the course of illness in 101 patients who were in an
episode (the "index episode") of major depressive disorder when they
entered a clinical research study, recovered from that episode, and then
relapsed into a new episode (the "first prospective episode") of the
disorder. They found a 22% probability that these patients' first
prospective episode would last at least 1 year, similar to the 21% rate of
chronicity previously reported for the index episode. A long prior episode,
older age, and low family income were found to predict chronicity in the
first prospective episode.
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