Antithyroid antibodies in depressed patients



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	Articles by Nemeroff, C. B.
	Articles by Evans, D. L.

Am J Psychiatry 1985; 142:840-843
Copyright © 1985 by American Psychiatric Association

REGULAR ARTICLES

Antithyroid antibodies in depressed patients

CB Nemeroff, JS Simon, JJ Haggerty Jr and DL Evans

The presence of antithyroid (antimicrosomal and antithyroglobulin) antibodies was assessed in 45 psychiatric inpatients with prominent depressive symptoms (28 with DSM-III major depression). Nine patients (20%) had detectable titers of antithyroid antibodies, a rate considerably higher than the 5%-10% observed in the normal population. Each of these nine patients with symptomless autoimmune thyroiditis had normal baseline serum thyrotropin concentrations and normal thyroid function (as assessed by T4, T3 uptake, and free thyroxine index). These findings support the hypothesis of subtle thyroid dysfunction in a sizable sample of psychiatric inpatients with prominent depressive symptoms.

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