Am J Psychiatry 1985; 142:738-740
Copyright © 1985 by American Psychiatric Association
Effects of physostigmine on pulse, blood pressure, and serum epinephrine levels
DS Janowsky, SC Risch, LY Huey, B Kennedy and M Ziegler
In this study, the infusion of physostigmine in 14 patients with affective
disorder who were pretreated with methscopolamine caused significant and
often profound increases in the patients' epinephrine levels, pulse rates,
and blood pressure. Since physostigmine is being used experimentally in the
treatment of elderly subjects who have Alzheimer's disease, these
cardiovascular effects may have clinical importance.
