A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia



	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted
	Citation Map



	Email this article to a Colleague
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Add to My Articles & Searches
	Download to citation manager



	Citing Articles via HighWire
	Citing Articles via Google Scholar



	Articles by Baron, M.
	Articles by Lord, S.
	Search for Related Content



	PubMed Citation
	Articles by Baron, M.
	Articles by Lord, S.

Am J Psychiatry 1985; 142:447-455
Copyright © 1985 by American Psychiatric Association

REGULAR ARTICLES

A family study of schizophrenic and normal control probands: implications for the spectrum concept of schizophrenia

M Baron, R Gruen, JD Rainer, J Kane, L Asnis and S Lord

Morbidity risks for mental illness were determined in 750 first-degree relatives of chronic schizophrenic and normal control probands. Psychiatric disorders that were more frequent in relatives of schizophrenic probands than in relatives of normal control probands were chronic schizophrenia (5.8% versus 0.6%), schizotypal personality disorder (definite, 14.6% versus 2.1%; probable, 12.1% versus 6.5%), and paranoid personality disorder (7.3% versus 2.3%). The data suggest that schizotypal and paranoid personality disorders are genetically related to schizophrenia. The implications for schizophrenia research are discussed.

This article has been cited by other articles:

A. M. Saperstein, R. L. Fuller, M. T. Avila, H. Adami, R. P. McMahon, G. K. Thaker, and J. M. Gold
Spatial Working Memory as a Cognitive Endophenotype of Schizophrenia: Assessing Risk for Pathophysiological Dysfunction
Schizophr Bull, July 1, 2006; 32(3): 498 - 506.
[Abstract] [Full Text] [PDF]

Z. Delawalla, D. M. Barch, J. L. Fisher Eastep, E. S. Thomason, M. J. Hanewinkel, P. A. Thompson, and J. G. Csernansky
Factors Mediating Cognitive Deficits and Psychopathology Among Siblings of Individuals With Schizophrenia
Schizophr Bull, July 1, 2006; 32(3): 525 - 537.
[Abstract] [Full Text] [PDF]

F. Van Dael, D. Versmissen, I. Janssen, I. Myin-Germeys, J. van Os, and L. Krabbendam
Data Gathering: Biased in Psychosis?
Schizophr Bull, April 1, 2006; 32(2): 341 - 351.
[Abstract] [Full Text] [PDF]

K. S. Kendler
The Genetics of Schizophrenia: Chromosomal Deletions, Attentional Disturbances, and Spectrum Boundaries
Am J Psychiatry, September 1, 2003; 160(9): 1549 - 1553.
[Full Text] [PDF]

F. Schurhoff, A. Szoke, A. Meary, F. Bellivier, F. Rouillon, D. Pauls, and M. Leboyer
Familial Aggregation of Delusional Proneness in Schizophrenia and Bipolar Pedigrees
Am J Psychiatry, July 1, 2003; 160(7): 1313 - 1319.
[Abstract] [Full Text] [PDF]

E. W. Schubert and T. F. McNeil
Prospective Study of Adult Mental Disturbance in Offspring of Women With Psychosis
Arch Gen Psychiatry, May 1, 2003; 60(5): 473 - 480.
[Abstract] [Full Text] [PDF]

J. COID
Epidemiology, public health and the problem of personality disorder
The British Journal of Psychiatry, January 1, 2003; 182 (44): s3 - s10.
[Abstract] [Full Text] [PDF]

A. S. Brown, C. A. Schaefer, R. J. Wyatt, M. D. Begg, R. Goetz, M. A. Bresnahan, J. Harkavy-Friedman, J. M. Gorman, D. Malaspina, and E. S. Susser
Paternal Age and Risk of Schizophrenia in Adult Offspring
Am J Psychiatry, September 1, 2002; 159(9): 1528 - 1533.
[Abstract] [Full Text] [PDF]

K. S. Kendler
Hierarchy and Heritability: The Role of Diagnosis and Modeling in Psychiatric Genetics
Am J Psychiatry, April 1, 2002; 159(4): 515 - 518.
[Full Text] [PDF]

A. Fanous, C. Gardner, D. Walsh, and K. S. Kendler
Relationship Between Positive and Negative Symptoms of Schizophrenia and Schizotypal Symptoms in Nonpsychotic Relatives
Arch Gen Psychiatry, July 1, 2001; 58(7): 669 - 673.
[Abstract] [Full Text] [PDF]

R. F. Asarnow, K. H. Nuechterlein, D. Fogelson, K. L. Subotnik, D. A. Payne, A. T. Russell, J. Asamen, H. Kuppinger, and K. S. Kendler
Schizophrenia and Schizophrenia-Spectrum Personality Disorders in the First-Degree Relatives of Children With Schizophrenia: The UCLA Family Study
Arch Gen Psychiatry, June 1, 2001; 58(6): 581 - 588.
[Abstract] [Full Text] [PDF]

K. S. Cadenhead, G. A. Light, M. A. Geyer, and D. L. Braff
Sensory Gating Deficits Assessed by the P50 Event-Related Potential in Subjects With Schizotypal Personality Disorder
Am J Psychiatry, January 1, 2000; 157(1): 55 - 59.
[Abstract] [Full Text]

R. M. Murray and A. Foerster
Schizophrenia: is the concept disintegrating?
J Psychopharmacol, January 1, 1987; 1(3): 133 - 139.
[PDF]

Get information about faster international access.