The pharmacological treatment of delusional depression



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Am J Psychiatry 1985; 142:430-436
Copyright © 1985 by American Psychiatric Association

BRIEF REPORTS

The pharmacological treatment of delusional depression

DG Spiker, JC Weiss, RS Dealy, SJ Griffin, I Hanin, JF Neil, JM Perel, AJ Rossi and PH Soloff

The authors investigated the pharmacological treatment of delusional depression by assigning patients on a random double-blind basis to amitriptyline alone, perphenazine alone, or a combination of the two. Fourteen (78%) of the 18 patients assigned to amitriptyline plus perphenazine were responders, compared with seven (41%) of 17 patients treated with amitriptyline alone and three (19%) of the 16 patients treated with perphenazine alone. The combination of amitriptyline and perphenazine was clearly superior (p less than .01).

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